With new artistic collaborators, Brian Michael Bendis shakes up the Ultimate Spider-Man's world! The Green Goblin escapes from prison - and he wants Peter Parker dead. Can Spidey's friends help him fend off the Goblin's vengeance-crazed attack? Meanwhile, one of Peter's classmates makes a startling discovery: She's a mutant! But when family secrets come to light, she may be forced to join Magneto's Brotherhood! Then symbiotes return - and as Venom takes on Carnage, Gwen Stacy's life hangs in the balance! And life will change forever when Magneto issues a terrifying Ultimatum and unleashes a tidal wave on Manhattan. Amid the chaos, villains see opportunity - and the up-and-coming Mysterio targets Spider-Man for elimination by any means necessary! Will a sinister imposter damage Peter's life beyond repair? Collecting ULTIMATE SPIDER-MAN (2000) #112-133 and ANNUAL #3, ULTIMATUM: SPIDER-MAN REQUIEM #1-2, and ULTIMATE SPIDER-MAN (2009) #1-15. Rated T